陈报恩 科创青年卓越人才
博士，浙大“百人计划”研究员
职务：合成生物所 PI
研究方向：基于化学生物学与合成生物学的新药发现
邮箱:bechen@zju.edu.cn 电话：0571-88981837
地址：杭州市萧山区建设三路733号浙江大学杭州国际科创中心
个人简介：
陈报恩，2013年博士毕业于中国科学院上海药物研究所。2014-2019年在哈佛医学院开展博士后研究，2019年4月任哈佛医学院讲师，2021年加入浙江大学生命科学研究院任研究员。长期致力于生物大分子修饰及新药靶点确证等交叉科学研究，成果发表在Cancer Cell, Nat Chem Biol, PNAS, JACS等。获国家自然科学基金项目资助，被ChemBioChem 杂志评选为“ChemBioTalents”。
学术兼职：
Chemical Biology Letters期刊编委
发表论文：
1. Wang Z, Zhang H, Chen B, Ouyang S, Zheng T, Zhou R, Dong Z, Huang Y, Zhang T, Jiang H, Gan J, Luo C*, Yang CG*. A Peptide Binder of E3 Ligase Adaptor SPOP Disrupts Oncogenic SPOP‐Protein Interactions in Kidney Cancer Cells. Chinese Journal of Chemistry39, 274-280 (2021)
2. Chen B, Wu X*. Probing Substrate Preferences of Depalmitoylases. Cell Chemical Biology 26(1):3-6 (2019).
3. Chen B, Niu J, Kreuzer J, Zheng B, Jarugumilli GK, Haas W, Wu X*. Auto-fatty Acylation of Transcription Factor RFX3 Regulates Ciliogenesis. Proceedings of the National Academy of Sciences of the United States of America 115(36):E8403-E8412 (2018).
4. Chen B, Sun Y, Niu J, Jarugumilli GK, Wu X *. Protein lipidation in cell signaling and diseases: function, regulation and therapeutic opportunities. Cell Chemical Biology 25(7):817-831(2018).
5. Jarugumilli GK, Choi JR, Chan P, Yu M, Sun Y, Chen B, Niu J, DeRan M, Zheng B, Zoeller R, Lin C, Wu X*. Chemical Probe to Identify the Cellular Targets of the Reactive Lipid Metabolite 2-trans-Hexadecenal. ACS Chemical Biology. 13(5):1130-1136(2018).
6. Chen S, Zhu B, Yin C, Liu W, Han C, Chen B, Liu T, Li X, Chen X, Li C, Hu L, Zhou J, Xu ZX, Gao X, Wu X, Goding CR, Cui R*. Palmitoylation-dependent activation of MC1R prevents melanomagenesis. Nature 549(7672):399-403 (2017).
7. Chen B, Zheng B, DeRan M, Jarugumilli GK, Fu J, Brooks YS, Wu X*. ZDHHC7-Mediated S-Palmitoylation of Scribble Regulates Cell Polarity.Nature Chemical Biology12, 686-693 (2016).
This work described the mechanism of tumor-suppressor Scribble mislocalization and provided new therapeutic opportunities for advanced cancer.
8. Guo ZQ#, Zheng T#, Chen B#, Luo C#, Ouyang S#, Gong S, Li J, Mao LL, Lian F, Yang Y, Huang Y, Li L, Lu J, Zhang B, Zhou L, Ding H, Gao Z, Zhou L, Li G, Zhou R, Chen K, Liu J, Wen Y, Gong L, Ke Y, Yang SD, Qiu XB, Zhang N, Ren J, Zhong D, Yang CG*, Liu J*, Jiang H*. Small-molecule targeting of E3 ligase adaptor SPOP in kidney cancer.Cancer Cell 30, 474-84 (2016).
This work described a novel strategy for kidney cancer treatment by targeting mislocalized E3 ubiquitin ligase adaptor SPOP.
Featured in Nature Reviews Urology13, 630 (2016)
9. Zheng B, Jarugumilli GK, Chen B, Wu X*. Chemical Probes to Directly Profile Palmitoleoylation of Proteins. Chembiochem 17, 2022-2027 (2016).
10. Chen B, Gan JH*, Yang CG *. The complex structures of ALKBH2 mutants cross-linked to dsDNA reveal the conformational swing of β-hairpin. Science China Chemistry 57, 307-313 (2014). (Cover story).
11. Li X, Song B*, Chen X, Wang Z, Zeng M, Yu D, Hu D, Chen Z, Jin L, Yang S*, Yang C, Chen B.Crystal structure of a four-layer aggregate of engineered TMV CP implies the importance of terminal residues for oligomer assembly. PLoS One 8, e77717 (2013).
12. Chen B#, Ye F#, Yu L#, Jia G, Huang X, Zhang X, Peng S, Chen K, Wang M, Gong S, Zhang R, Yin J, Li H, Yang Y, Liu H, Zhang J, Zhang H, Zhang A, Jiang H, Luo C*, Yang CG*. Development of Cell-active N6-Methyladenosine RNA Demethylase FTO Inhibitor.Journal of the American Chemical Society134,17963-71 (2012).
This paper described the first inhibitor of mRNA demethylase FTO. The work has been reviewed by several renowned scientific journals, includingNature Reviews Molecular Cell Biology 15, 313-326 (2014); Chemical reviews 114(8): 4602-20 (2014)
13. Yi C, Chen B, Qi B, Zhang W, Jia G, Zhang L, Li CJ, Dinner AR, Yang CG*, He C*. Duplex interrogation by a direct DNA repair protein in search of base damage. Nature Structural & Molecluar Biology19, 671-676 (2012). (Cover story).
14. Chen B, Liu H, Sun X, Yang CG*. Mechanistic insight into the recognition of single-stranded and double-stranded DNA substrates by ABH2 and ABH3. Molecular BioSystems6, 2143-49 (2010).
Book chapter
Chen B*, Guarino C, Azzi A, Erb H, Wu X *. ‘Regulation of cell polarity by posttranslational protein palmitoylation’. Methods in Molecular Biology 2438, 107-121 (2022).
