张琪 求是科创学者
博士，研究员，“浙大科创百人”
职务：分子智造所 PI
研究方向：不对称催化，仿生催化
邮箱:qiqiyape@zju.edu.cn
地址：杭州市萧山区建设三路733号浙江大学杭州国际科创中心
个人简介：
张琪博士2011年和2016年先后于浙江大学化学系取得理学学士学位，化学专业博士学位，师从史炳锋教授。博士期间研究钯催化惰性碳氢键活化，获得浙江大学优秀博士学位论文、浙江省优秀博士学位论文。2016-2018年作为洪堡学者赴德国马尔堡大学从事博士后研究，进行八面体手性催化剂的设计和应用，其后回到浙江大学化学系进一步研究不对称催化。求学和博士后研究期间，作为第一作者在Acc. Chem. Res., Chem, J. Am. Chem. Soc., Angew. Chem. Int. Ed., Chem. Sci.等国际顶级化学杂志发表多篇论文，其中ESI高被引论文4篇，论文总被引次数超过1000次。2021年8月入选浙江大学杭州国际科创中心“科创百人”人才计划，研究员。课题组致力于将人工智能、自动化合的技术手段相结合，发展新型不对称催化方法学，实现从廉价易得的原料向高附加值的手性材料、药物分子的转化。
论文发表：
1. Zhang, Q.; Chen, K.; Rao, W.; Zhang, Y.; Chen, F.-J.; Shi, B.-F.*; Stereoselective Synthesis of Chiral α-Amino-β-Lactams through Palladium(II)-Catalyzed Sequential Monoarylation/Amidation of C(sp3)−H Bonds, Angew. Chem. Int. Ed.2013, 52, 13588-13592.
² Highlighted in Synfacts 2014, 0252.
² Highlighted in Chin. J. Org. Chem. 2014, 34, 434-436.
² Highlighted in ChemInform 2014, 45, May 27, DOI: 10.1002/chin.201421112.
2. Zhang, Q.; Yin, X.-S.; Chen, K.; Zhang, S.-Q.; Shi, B.-F.*; Stereoselective Synthesis of Chiral β-Fluoro α-Amino Acids via Pd(II)-Catalyzed Fluorination of Unactivated Methylene C(sp3)−H Bonds: Scope and Mechanistic Studies, J. Am. Chem. Soc.2015, 137, 8219-8226.
3. Zhang, Q.; Shi, B.-F.*; 2-(Pyridin-2-yl)isopropyl (PIP) Amine: An Enabling Directing Group for Divergent and Asymmetric Functionalization of Unactivated Methylene C(sp3)–H Bonds, Acc. Chem. Res.2021,54, 2750-2763.
4. Zhang, Q.; Wu, L.-S.; Shi, B.-F.*; Forging C–heteroatom bonds by transition metal-catalyzed enantioselective C–H functionalization, Chem2021, DOI: 10.1016/j.chempr.2021.11.015.
5. Huang, X.; Zhang, Q.; Lin, J.; Harms, K.; Meggers, E.*; Electricity-driven asymmetric Lewis acid catalysis, Nat. Catal.2019, 2, 34-40.
6. Zhang, Q.; Shi, B.-F.*; Site-selective functionalization of remote aliphatic C–H bonds via C–H metallation,Chem. Sci.2020, 12, 841-852.
7. Zhang, Q.#; Yin, X.-S.#; Zhao, S.; Fang, S.-L.; Shi, B.-F.*;Pd(II)-Catalyzed Arylation of Unactivated Methylene C(sp3)−H bonds with Aryl Halides Using a Removable Auxiliary,Chem. Commun.2014, 50, 8353-8355. (# equal contribution)
² Highlighted in ChemInform 2014, 45, December 29, DOI: 10.1002/chin.201452040.
8. Zhang, Q.; Shi, B.-F.*;From Reactivity and Regioselectivity to Stereoselectivity: An Odyssey of Designing PIP Amine and Related Directing Groups for C-H Activation, Chin. J. Chem. 2019, 37, 647-656.
9. Zhang, Q.; Chen, K.; Shi, B.-F.*; Recent Progress in the Synthesis of Functionalized β-Lactams through Transition-Metal-Catalyzed C(sp3)−H Amidation, Synlett2014, 25, 1941-1945.
10. Han, Y.-Q.#; Zhang, Q.#; Yang, X.; Jiang, M.-X.; Ding, Y.; Shi, B.-F.*; Pd(II)-Catalyzed Enantioselective Intramolecular Arylation of Unbiased C(sp3)–H Bonds to Construct Benzo-ring Compounds,Org. Lett. 2021, 23, 97-101. (# equal contribution)
11. Chen, F.-J.; Zhao, S.; Hu, F.; Chen, K.; Zhang, Q.; Zhang, S.-Q.; Shi, B.-F.*; Pd(II)-Catalyzed Alkoxylation of Unactivated C(sp3)−H and C(sp2)−H Bonds Using a Removable Directing Group: Efficient Synthesis of Alkyl Ethers, Chem. Sci.2013, 4, 4187-4192.
² Highlighted by ChemInform2014, 45, March 11, DOI: 10.1002/chin.201410049.
12. Ling, P.-X.; Fang, S.-L.; Yin, X.-S.; Zhang, Q.; Chen, K.; Shi, B.-F.*; Palladium-catalyzed sequential monoarylation/amidation of C(sp3)-H bonds: stereoselective synthesis of alpha-amino-beta-lactams and anti-alpha,beta-diamino acid, Chem. Commun., 2017, 53, 6351-6354.
13. Liao, G.; Yin, X.-S.; Chen, K.; Zhang, Q.; Zhang, S.-Q.; Shi, B.-F.*; Stereoselective alkoxycarbonylation of unactivated C(sp3)-H bonds with alkyl chloroformates via Pd(II)/Pd(IV) catalysis, Nat. Commun. 2016, 7, 12901-12909.
专著章节
Li, Y.; Zhang, Q.; Shi B.-F.*; Directing Group Assisted Distal C(sp3)-H Functionalization of Aliphatic Substrates in Remote C-H Bond Functionalizations: Methods and Strategies in Organic Synthesis (Ed: Debabrata Maiti), Wiley-VCH. 2020.
