都浩 科创青年卓越人才
博士，浙江大学长聘副教授
职务：合成生物所 PI
研究方向：植物合成生物技术开发及应用
地址：杭州市萧山区平澜路2118号浙江大学杭州国际科创中心
个人简介：
都浩，浙江大学长聘副教授、博士生导师。微信号：duhaoboston，籍贯：安徽省亳州市蒙城县。
2003年考入华中农业大学生科院生命科学技术人才培养基地班，
2006年师从华中农业大学作物遗传改良国家重点实验室熊立仲教授，从事水稻逆境生物学研究，
2007年获得华中农业大学理学学士学位，
2013年6月获得生物化学与分子生物学博士学位，
2013年至2015年4月在华中农业大学作物遗传改良国家重点实验室熊立仲教授实验室做Research Associate，
2015年5月进入哈佛大学医学院Jen Sheen教授实验室做博士后研究，主要从事植物能量调控机制相关研究，
2019年底以“百人计划”研究员加入浙江大学农业生物技术学院，
2021年初入选浙江大学杭州国际科创中心卓越人才计划，合成生物研究所双聘研究员。目前与浙江大学医学院、生科院、化学工程与生物工程学院、计算机科学与技 术学院等开展交叉学科研究，至今累计发表SCI收录研究论文四十多篇，累计引用5000余次。
科研成果：
基于农学、生物学、化学与AI 的深度交叉融合，创新植物合成生物技术，对植物基因组进行设计改造，制造“超级植物”，提升植物价值，推动农业高质量发展！主要研究内容：1. 基于新型生物光示踪技术系统，构建植物合成生物技术体系（蛋白酶定向进化与从头设计；基因线路优化；多基因靶向调控；植物元件库构建；转基因技术等）；2. 利用植物合成生物技术创制高亮度自发光植物和碳氮高效利用农作物新种质。自2023年以来，主持包括国家自然科学基金原创探索项目、国际合作项目及面上项目等多项国家级和省部级项目、横向项目十余项，申请国家发明专利十余项，获批国家发明专利8项，专利转化到账210万。以独立通讯作者在Nature Food、Molecular Plant、Plant Cell、Trends in Biotechnology、New Phytologist、Plant Communications、Plant, Cell & Environment、BioDesign Research等国际重要期刊发表论文十余篇。
Publications (*通讯作者):
2025
1. Xiaolei Yu#, Pengliang Wei #, Chengyi Qu, Ci Kong, Hao Du*. Sustainable bioenergy manufacturing in plants. Plant Commun. 2025. (In press)
2. Jieyu Ge#, Tiange Wang#, Chengyi Qu#, Anastasia V. Balakireva, Ilia V. Yampolsky*, Hao Du*. Biotechnologies based on the fungal bioluminescence pathway. Trends in Biotechnology, 2025 Oct 30:S0167-7799(25)00418-4.
3. Siyuan Sun#, Tiange Wang#, Yingzi Li, Hao Du*. Advances in luminescence-based tracing technologies: applications and future perspectives. BioDesign Research, 2025 Oct 31. (In press)
4. TG, Wang, JY, Ge, CY, Qu, HY, Chen, J, Li, S, Wang, XY, Guan, T. Chen, ZF. Si, KM, Hu, XH, Ding, L, Liu, J. Zhang, AS. Mishin, IV. Yampolsky. Hao Du*. Developing a versatile technology for agroinfiltration in multiple plants, bioRXiv, 2025.
5. Xiaolei Yu#; Tiange Wang#; Ci Kong; Hao Du*. Engineering autonomously luminescent plants using the fungal bioluminescence pathway. New Phytologist, 2025 Dec;248(5):2251-2261. doi: 10.1111/nph.70601..
6. Pengliang Wei#, Shiquan Li#, Huayi Hu, Hao Du*. Low-Carbon Agricultural Innovations Address the Challenge of Climate Change. Plant, Cell & Environment, 2025,doi: 10.1111/pce.70130
7. Yuhao Li#, Dang Xu#, Hao Du*. Advances and applications of the fungal bioluminescence pathway. Crop Design. 4 (2025) 100111.
8. Jin Zhang,*, Hao Du, Meng-Zhu Lu*. Illuminating plants: autoluminescence through big data mining and metabolic optimization. Trends in Plant Science, 2025, doi: 10.1016/j.tplants.2024.11.002.
9. Siyuan Sun#, Qiye Ni#, Daren Luo#, Xiao Hong, Wei Li, Tiange Wang, Xuye Lang, Hao Du*. Development of an FBP-based bioluminescence reporter system for investigating transcriptional regulation in plants. Plant Commun. 2025, 6(1):101143. doi: 10.1016/j.xplc.2024.101143.
2024
1. Zeqi Li, Yi Zhang, Hao Du*. Upland rice retains genetic elements conferring drought adaptation. Molecular Plant. 2024, doi: 10.1016/j.molp.2024.10.006.
2. Bo Bi, Lingmei Shao, Tong Xu, Hao Du, Danqing Li*. Transcriptomic Analysis Reveals Calcium and Ethylene Signaling Pathway Genes in Response to Cold Stress in Cinnamomum camphora. Horticulturae, 2024, 10(9), 995.
3. Jieyu Ge#, Xuye Lang#, Jiayi Ji#, Chengyi Qu#, He Qiao#, Jingling Zhong, Daren Luo, Jin Hu, Hongyu Chen, Shun Wang, Tiange Wang, Shiquan Li, Wei Li, Peng Zheng，Jiming Xu, Hao Du*. Integration of biological and information technologies to enhance plant autoluminescence. Plant Cell, 2024, 36(11):4703-4715. DOI: 10.1093/plcell/koae236.
4. Huayi Hu, Hao Du*. A comprehensive framework for the production of plant-based molecules. Nature Food. 2024, doi: 10.1038/s43016-024-00995-y.
5. Wei Li#, Jiaqi Liu#, Zeqi Li#, Ruiqiang Ye, Wenzhen Chen, Yuqing Huang, Yue Yuan, Yi Zhang, Huayi Hu, Peng Zheng, Zhongming Fang, Zeng Tao, Shiyong Song, Ronghui Pan, Jian Zhang, Jumim Tu, Jen Sheen, Hao Du* Mitigating growth-stress tradeoffs via elevated TOR signaling in rice. Molecular Plant, 2024, 17(2):240-257.
6. Xixi Liu, Zhiyong Li, Jiezheng Ying, Yazhou Shu, Wanning Liu, Guanghao Li, Lijuan Chen, Jinjin Luo, Shiyi Wang, Yifeng Wang, Xiaohong Tong, Jie Huang, Hao Du, Jian Zhang*.Multi-gene Engineering Boosts Oil Content in Rice Grains. Plant Commun. 2024, 5(2):100736.
In the year of 2023 and before
1. Peng Zheng, Jieyu Ge, Jiayi Ji, Jingling Zhong, Hongyu Chen, Daren Luo, Wei Li, Bo Bi, Yongjun Ma, Wanghui Tong, Leiqin Han, Siqi Ma, Yuqi Zhang, Jianping Wu, Yanqiu Zhao, Ronghui Pan, Pengxiang Fan, Mengzhu Lu, Hao Du*. Metabolic engineering and mechanical investigation of enhanced plant autoluminescence. Plant Biotechnol J, 2023 Aug;21(8):1671-1681. doi: 10.1111/pbi.14068.
2. Ruiqiang Ye, Meiyue Wang, Hao Du, Shweta Chhajed, Jin Koh, Kun-hsiang Liu,Jinwoo Shin, Yue Wu, Lin Shi, Lin Xu, Sixue Chen, Yijing Zhang, Jen Sheen* Glucose-Driven TOR-FIE-PRC2 signalling controls plant development. Nature, 2022, 609(7929):986-993.
3. Bo Bi, Wei Li, Yushu Jiang, Hao Du*. Present and future prospects of crop synthetic biology.2022. Crop Design, 2022, Nov. 100017.
4. Wu N, Yao Y, Xiang D, Du H, Geng Z, Yang W, Li X, Xie T, Xiong L*. A MITE variation-associated heat-inducible isoform of a heat-shock factor confers heat tolerance through regulation of JASMONATE ZIM-DOMAIN genes in rice. New Phytol. 2022 May;234(4):1315-1331.
5. Jan Mehmood, Shah Gulmeena, Yuqing Huang, Xuejiao Liu, Peng Zheng, Hao Du, Hao Chen*, Jumin Tu. Development of Heat Tolerant Two-Line Hybrid Rice Restorer Line Carrying Dominant Locus of OsHTAS. Rice Science. 2021, 28 (1): 99-108.
6. Liu X, Sun J, Huang Y, Li C, Zheng P, Yuan Y, Chen H, Jan M, Zheng H, Du H*, Tu J* .Osj10gBTF3-mediated import of chloroplast protein is essential for pollen development in rice. Front Plant Sci. 2021 Aug 6;12:713544.
7. Chen Y, Shen J, Zhang L, Qi H, Yang L , Wang H, Wang J, Wang Y, Du H, Tao Z, Zhao T, Deng P, Shu Q, Qian Q, Yu H, Song S* Nuclear translocation of OsMFT1 that is impeded by OsFTIP1 promotes drought tolerance in rice. Molecular Plant, 2021 Aug 2;14(8):1297-1311.
8. Zheng P, Liu Y, Liu X, Huang Y, Sun F, Chen H, Wang W, Jan M, Zhang C, Yuan Y, Tan B, Du H*,Tu J*.OsPPR939, a nad5 splicing factor, is essential for plant growth and pollen development in rice. Theor Appl Genet 2021.134(3):923-940.
9. Zheng P, Wang D, Huang Y, Chen H, Du H*, Tu J*. Detection and Analysis of C-to-U RNA Editing in Rice Mitochondria-Encoded ORFs. Plants (Basel). 2020. 28;9(10):E1277.
10. Tan, Y. Du, H. Wu, X. Liu, Y. Jiang, M. Song, S.Wu, L. Shu, Q*. Gene editing: an instrument for practical application of gene biology to plant breeding. J Zhejiang Univ Sci B. 2020. 21(6):460-473.
11. Maheshwari, P., Du, H., Sheen, J., Assman, S., and Albert, R*.Model-driven discovery of calcium-related protein-phosphatase inhibition in plant guard cell signaling. PLoS Comput Biol. 2019. 15(10):e1007429.
12. Zhang, R. Ge, S. He, Ji. Li, S. Hao, Y. Du, H. Liu, Z. Cheng, R. Feng, Y. Xiong, L. L,i C. Hetherington.M. Liang, Y*. BIG regulates stomatal immunity and jasmonate production in Arabidopsis. New Phytol. 2019. 222(1):335-348.
13. Du, H., Huang, F., Wu, N., Li, X., Hu, H., and Xiong, L*. Integrative Regulation of Drought Escape through ABA-Dependent and -Independent Pathways in Rice. Molecular Plant.2018. 11:584-597.
14. Liu KH#*, Niu Y#, Konishi M, Wu Y, Du H, Sun Chung H, Li L, Boudsocq M, McCormack M, Maekawa S, Ishida T, Zhang C, Shokat K, Yanagisawa S, Sheen J*.Discovery of nitrate-CPK-NLP signalling in central nutrient-growth networks. Nature. 2017. 545:311-316.
15. Fang Y, Liao K, Du H, Xu Y, Song H, Li X, Xiong L*. A stress-responsive NAC transcription factor SNAC3 confers heat and drought tolerance through modulation of reactive oxygen species in rice. J Exp Bot. 2015. 66(21):6803-6817.
16. Zhu, N. Cheng, S. Liu, X. Du, H. Dai, M. Zhou, D. Yang, W. Zhao, Y*. The R2R3-type MYB gene OsMYB91 has a function in coordinating plant growth and salt stress tolerance in rice. Plant Sci. 2015. 236:146-156.
17. Du H*. Chang Y. Huang F, Xiong L. GID1 modulates stomatal response and submergence tolerance involving ABA and GA signaling in rice. J Integr Plant Biol. 2015. 57(11):954-968.
18. Du H, Wu N, Cui F, You L, Li X, Xiong L*. A homolog of ETHYLENE OVERPRODUCER, OsETOL1, differentially modulates drought and submergence tolerance in rice. Plant J. 2014. 78: 834-849.
19. Weng X, Wang L, Wang J, Hu Y, Du H, Xu C, Xing Y, Li X, Xiao J, Zhang Q*. Grain number, plant height, and heading date7 is a central regulator of growth, development, and stress response. Plant Physiol. 2014.164:735-747.
20. Du, H. and Xiong, L*. (2014) Improvement of Stress Tolerance in Crops by Genetic Manipulation of ABA Metabolism, Signaling, and Regulation. (Chapter 22), ISBN: 978-94-017-9423-7 (Print) 978-94-017-9424-4 (Online). (springer)
21. You,J. Zong,W. Du,H. Hu,H. Xiong,L*.A special member of the rice SRO family, OsSRO1c, mediates responses to multiple abiotic stresses through interaction with various transcription factors. Plant Mol Biol. 2014. 84(6):693-705.
22. Du, H. Liu, H. Xiong, L*. Endogenous auxin and jasmonic acid levels are differentially modulated by abiotic stresses in rice. Front Plant Sci. 2013 Oct. eCollection 2013.
23. Du, H. Wu, N. Chang, Y. Li, X. Xiao, J. Xiong, L*. Carotenoid deficiency impairs ABA and IAA biosynthesis and differentially affects drought and cold tolerance in rice. Plant Mol Biol. 2013. 83(4-5):475-488.
24. Du, H. Wu, N. Fu, J. Wang, S. Li, X. Xiao, J. Xiong, L*.A GH3 family member, OsGH3-2, modulates auxin and abscisic acid levels and differentially affects drought and cold tolerance in rice. J Exp Bot. 2012.63: 6467-6480.
25. Du, H. Liu, L. You, L. Yang, M. He, Y. Li, X. Xiong, L*. Characterization of an inositol 1,3,4-trisphosphate 5/6-kinase gene that is essential for drought and salt stress responses in rice. Plant Mol Biol. 2011.77: 547-563.
26. Du, H. Wang, N. Cui, F. Li, X. Xiao, J. Xiong, L*. Characterization of the beta-carotene hydroxylase gene DSM2 conferring drought and oxidative stress resistance by increasing xanthophylls and abscisic acid synthesis in rice. Plant Physiol. 2010.154:1304-1318.
27. Ye, H. Du, H. Tang, N. Li, X. Xiong, L*. Identification and expression profiling analysis of TIFY family genes involved in stress and phytohormone responses in rice. Plant Mol Biol. 2009. 71: 291-305.
28. Islam, M. Du, H. Ning, J. Ye, H. Xiong, L*. Characterization of Glossy1-homologous genes in rice involved in leaf wax accumulation and drought resistance. Plant Mol Biol. 2009. 70: 443-456.
29. Xiang, Y. Tang, N. Du, H. Ye, H. Xiong, L*. Characterization of OsbZIP23 as a key player of the basic leucine zipper transcription factor family for conferring abscisic acid sensitivity and salinity and drought tolerance in rice. Plant Physiol. 2008.148: 1938-1952.
英文专著：
Du H. and Xiong L. Improvement of Stress Tolerance in Crops by Genetic Manipulation of ABA Metabolism, Signaling, and Regulation. (Chapter 22), ISBN: 978-94-017-9423-7 (Print) 978-94-017-9424-4 (Online). (springer) 5303 (2014)
友情链接：
浙江大学个人主页：https://person.zju.edu.cn/0019057
