鲍泽华 科创青年卓越人才
博士，浙大“百人计划”研究员
职务：合成生物所 PI
研究方向：合成生物学
邮箱:zbao@zju.edu.cn
地址：杭州市萧山区建设三路733号浙江大学杭州国际科创中心
个人简介：
鲍泽华博士，浙江大学化学工程与生物工程学院合成生物学研究中心研究员、博导，浙大杭州国际科创中心生物与分子智造平台PI，入选国家级青年人才计划、浙江大学“百人计划”以及杭州国际科创中心青年人才卓越计划。2010年获得清华大学生物科学与技术学士学位，2017年于美国伊利诺伊大学香槟分校Huimin Zhao课题组取得生物化学博士学位，后于波士顿大学生物设计中心Ahmad Khalil课题组接受博士后训练。迄今在Nat Biotechnol、ACS Synth Biol等专业期刊发表论文多篇，担任BMC Biotechnol编委，研究领域包括基因组工程、表观基因组工程、定向进化等。
发表论文：
1. J. You, N. Singh, A. Reyes-Ordonez, N. Khanna, Z. Bao, H. Zhao, J. Chen (2020) ARHGEF3 regulates skeletal muscle regeneration and strength through autophagy. Cell Reports (Accepted)
2. Z. Bao, M. HamediRad, P. Xue, H. Xiao, I. Tasan, R. Chao, J. Liang, H. Zhao (2018) Genome-scale engineering of Saccharomyces cerevisiae with single nucleotide precision. Nature Biotechnology 36 (6), 505-508.
· Highlighted by U.S. Department of Energy, AAAS, Illinois News Bureau, etc.
3. J. Lian, Z. Bao, S. Hu, H. Zhao (2018) Engineered CRISPR/Cas9 system for multiplex genome engineering of polyploid industrial yeast strains. Biotechnology and Bioengineering 115 (6), 1630-1635.
4. Z. Bao, S. Jain, V. Jaroenpuntaruk, H. Zhao (2017) Orthogonal genetic regulation in human cells using chemically induced CRISPR/Cas9 activators. ACS Synthetic Biology 6 (4), 686-693.
· Recommended by F1000Prime
5. Z. Jin, T. Schwend, J. Fu, Z. Bao, J. Liang, H. Zhao, W. Mei, J. Yang (2016) Members of the Rusc protein family interact with Sufu and inhibit vertebrate hedgehog signaling. Development 143 (21), 3944-3955.
· Highlighted article: Regulating Hh signaling with Rusc. Development 2016 143: e2014
6. Z. Bao*, H. Xiao*, J. Liang, L. Zhang, X. Xiong, N. Sun, T. Si, H. Zhao (2014) Homology-Integrated CRISPR-Cas (HI-CRISPR) system for one-step multigene disruption in Saccharomyces cerevisiae. ACS Synthetic Biology 4 (5), 585-594.
· ESI highly cited paper
7. T. Si, Y. Luo, Z. Bao, H. Zhao (2014) RNAi-assisted genome evolution in Saccharomyces cerevisiae for complex phenotype engineering. ACS Synthetic Biology 4 (3), 283-291.
8. N. Sun, Z. Bao, X. Xiong, H. Zhao (2014) SunnyTALEN: a second-generation TALEN system for human genome editing. Biotechnology and Bioengineering 111 (4), 683-691.
· Selected as a spotlight article in Biotechnol Bioeng, Vol. 111, No. 4, April, 2014
9. J. Liang, R. Chao, Z. Abil, Z. Bao, H. Zhao (2014) FairyTALE: a high-throughput TAL effector synthesis platform. ACS Synthetic Biology 3 (2), 67-73.
· Recommended by F1000Prime
· Highlighted in ACS Synth. Biol. 2014, 3, 52-53
10. K. Yu, Z. Ming, Y. Li, C. Chen, Z. Bao, Z. Ren, B. Liu, W. Tao, Z. Rao, Z. Lou (2012) Purification, crystallization and preliminary X-ray analysis of nonstructural protein 2 (nsp2) from avian infectious bronchitis virus. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications 68 (6), 716-719.
11. Y. Li, Z. Ren, Z. Bao, Z. Ming, X. Li (2011) Expression, crystallization and preliminary crystallographic study of the C-terminal half of nsp2 from SARS coronavirus. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications 67 (7), 790-793.
综述文章：
1. Z. Bao*, R. E. Cobb*, H. Zhao (2016) Accelerated genome engineering through multiplexing. Wiley Interdisciplinary Reviews Systems Biology and Medicine 8 (1), 5-21.
· Top ten accessed WSBM articles in 2016
2. H. Xiao*, Z. Bao*, H. Zhao (2014) High throughput screening and selection methods for directed enzyme evolution. Industrial & Engineering Chemistry Research 54 (16), 4011-4020.
