张琪 求是科创学者
博士，研究员
职务：求是科创学者
研究方向：有机合成，不对称催化，仿生催化
邮箱:qiqiyape@zju.edu.cn
地址：杭州市萧山区平澜路2118号浙江大学杭州国际科创中心
个人简介：
张琪博士2011年和2016年先后于浙江大学化学系取得理学学士学位，理学博士学位，师从史炳锋教授。随后在德国马尔堡大学、浙江大学从事博士后研究。曾获得浙江大学优秀博士学位论文、浙江省优秀博士学位论文，德国洪堡奖学金等荣誉。2021年作为科创“百人计划”研究员加入浙江大学杭州国际科创中心，主要研究兴趣是结合人工智能、自动化合成装置技术，开发不对称催化新方法，并应用于新药研发等领域。
科研项目：
1. 浙江省自然科学基金重点项目，新型瞬态导向基促进的游离醇直接sp3碳氢键活化研究，2025-2027，在研，主持
2. 国家自然科学基金青年项目,钯-羰基协同催化裸露伯胺中惰性亚甲基不对称sp3碳氢键活化及其合成应用，2023-2025，结题，主持
3. 中国博士后自然科学基金面上项目，2019-2020，结题，主持
代表性论文：
1. Yu, X.#; Liu, S.#; Wang, L.#; Li, Y.; Huang, M.; Yan, Z.-Y.; Li, H.-C.; Zhang, Q.*; Zhang, X.*; Shi, B.-F.*; Novel Sulfinamide-Based Chiral Ligand Promoted Chiral Diarylmethanol Preparation via exo-Directed Asymmetric C–H Alkynylation under Mild Conditions. ACS Catal. 2025, 15, 2540-2549. (# equal contribution, IF: 13.1, Cited Times: 5)
2. Jin, L.#; Li, Y.#; Mao, Y.#; He, X.-B.; Lu, Z.; Zhang, Q.*; Shi, B.-F.*; Chiral dinitrogen ligand enabled asymmetric Pd/norbornene cooperative catalysis toward the assembly of C–N axially chiral scaffolds. Nat. Commun. 2024, 15, 4908. (# equal contribution, IF: 15.7, Cited Times: 18)
3. Li, D.#; He, X.-B.#; Jin, L.; Yu, X.; Zhang, Q.*; Palladium catalyzed C(sp3)–H bond activation of free carboxylic acids: An adventure of ligand evolution. Tetrahedron Lett. 2024, 138, 154951. (#equal contribution, IF: 1.5, Cited Times: 4)
4. Zhang, Q.; Wu, L.-S.; Shi, B.-F.*; Forging C–heteroatom bonds by transition metal-catalyzed enantioselective C–H functionalization, Chem 2022, 8, 384-413. (IF: 19.6, Cited Times: 120)
5. Zhang, Q.; Shi, B.-F.*; 2-(Pyridin-2-yl)isopropyl (PIP) Amine: An Enabling Directing Group for Divergent and Asymmetric Functionalization of Unactivated Methylene C(sp3)–H Bonds, Acc. Chem. Res. 2021, 54, 2750-2763. (IF: 17.7, Cited Times: 155)
6. Han, Y.-Q.#; Zhang, Q.#; Yang, X.; Jiang, M.-X.; Ding, Y.; Shi, B.-F.*; Pd(II)-Catalyzed Enantioselective Intramolecular Arylation of Unbiased C(sp3)–H Bonds to Construct Benzo-ring Compounds, Org. Lett. 2021, 23, 97-101. (# equal contribution, IF: 5, Cited Times: 22)
7. Zhang, Q.; Shi, B.-F.*; Site-selective functionalization of remote aliphatic C–H bonds via C–H metallation, Chem. Sci. 2020, 12, 841-852. (IF: 7.5, Cited Times: 85)
8. Zhang, Q.; Shi, B.-F.*; From Reactivity and Regioselectivity to Stereoselectivity: An Odyssey of Designing PIP Amine and Related Directing Groups for C-H Activation, Chin. J. Chem. 2019, 37, 647-656. (IF: 5.5, Cited Times: 128)
9. Huang, X.; Zhang, Q.; Lin, J.; Harms, K.; Meggers, E.*; Electricity-driven asymmetric Lewis acid catalysis, Nat. Catal. 2019, 2, 34-40. (IF: 44.6, Cited Times: 166)
10. Ling, P.-X.; Fang, S.-L.; Yin, X.-S.; Zhang, Q.; Chen, K.; Shi, B.-F.*; Palladium-catalyzed sequential monoarylation/amidation of C(sp3)-H bonds: stereoselective synthesis of alpha-amino-beta-lactams and anti-alpha,beta-diamino acid, Chem. Commun., 2017, 53, 6351-6354. (IF: 4.2, Cited Times: 39)
11. Liao, G.; Yin, X.-S.; Chen, K.; Zhang, Q.; Zhang, S.-Q.; Shi, B.-F.*; Stereoselective alkoxycarbonylation of unactivated C(sp3)-H bonds with alkyl chloroformates via Pd(II)/Pd(IV) catalysis, Nat. Commun. 2016, 7, 12901-12909. (IF: 15.7, Cited Times: 72)
12. Zhang, Q.; Yin, X.-S.; Chen, K.; Zhang, S.-Q.; Shi, B.-F.*; Stereoselective Synthesis of Chiral β-Fluoro α-Amino Acids via Pd(II)-Catalyzed Fluorination of Unactivated Methylene C(sp3)−H Bonds: Scope and Mechanistic Studies, J. Am. Chem. Soc. 2015, 137, 8219-8226. (IF: 15.7, Cited Times: 173)
13. Zhang, Q.#; Yin, X.-S.#; Zhao, S.; Fang, S.-L.; Shi, B.-F.*; Pd(II)-Catalyzed Arylation of Unactivated Methylene C(sp3)−H bonds with Aryl Halides Using a Removable Auxiliary, Chem. Commun. 2014, 50, 8353-8355. (# equal contribution, IF: 4.2, Cited Times: 83)
14. Zhang, Q.; Chen, K.; Shi, B.-F.*; Recent Progress in the Synthesis of Functionalized β-Lactams through Transition-Metal-Catalyzed C(sp3)−H Amidation, Synlett 2014, 25, 1941-1945 (invited Synpacts review, IF: 1.4, Cited Times: 44).
15. Zhang, Q.; Chen, K.; Rao, W.; Zhang, Y.; Chen, F.-J.; Shi, B.-F.*; Stereoselective Synthesis of Chiral α-Amino-β-Lactams through Palladium(II)-Catalyzed Sequential Monoarylation/Amidation of C(sp3)−H Bonds, Angew. Chem. Int. Ed. 2013, 52, 13588-13592. (IF: 17, Cited Times: 298)
16. Chen, F.-J.; Zhao, S.; Hu, F.; Chen, K.; Zhang, Q.; Zhang, S.-Q.; Shi, B.-F.*; Pd(II)-Catalyzed Alkoxylation of Unactivated C(sp3)−H and C(sp2)−H Bonds Using a Removable Directing Group: Efficient Synthesis of Alkyl Ethers, Chem. Sci. 2013, 4, 4187-4192. (IF: 7.5, Cited Times: 292)
专利：
1. 周涛，张琪，于欣，范铃洁，一种手性苯乙烯基吡啶基亚砜及其合成方法。
