王熙，博士毕业于美国华盛顿州立大学，后于美国劳伦斯伯克利国家实验室 (Lawrence Berkeley National Laboratory)，能源部联合生物能源研究所(DOE Joint BioEnergy Institute)从事博士后研究。长期致力于微生物代谢工程与合成生物学研究，包括生物能源、生物制品的生物合成，计算机辅助生物系统设计与高通量研究平台的开发等。代表成果发表于Metabolic Engineering, Biotechnology Advances等期刊。

教学工作

UC Berkeley CHEM ENG H194 (Research for Advanced Undergraduate), 3-4学分/学期, 2017年夏季学期 – 2021年秋季学期, 指导教师

工作研究项目

• 本课题组重点研究方向为生物合成与微生物代谢工程，生物与信息交叉融合技术等。

• 生物合成：各类化合物的从头生物合成，无细胞生物合成

• 微生物代谢工程：代谢途径工程，菌株构建工程

• 藻类微生物的代谢工程与合成生物学研究

• 计算生物学：基因组尺度代谢模拟，计算机辅助生物系统设计

代表论文

1. Wang, X., Pereira J. H., Tsutakawa, S., Fang, X., Adams, P. D., Mukhopadhyay, A., Lee, T. S. Efficient production of oxidized terpenoids via engineering P450 fusion proteins. Metabolic Engineering, 2021, 64:41–51.

2. Wang, X., Goh, E., Beller, H. Engineering E. coli for simultaneous glucose-xylose utilization during methyl ketone production. Microbial Cell Factories, 2018, 17:12.

3. Wang, X., Yu, L., Chen, S. UP Finder: A COBRA toolbox extension for identifying gene overexpression strategies for targeted overproduction. Metabolic Engineering Communications, 2017, 5:54–59.

4. Wang, X., Xiong, X., Sa, N., Roje, S., Chen, S. Metabolic engineering of enhanced glycerol-3-phosphate synthesis to increase lipid production in Synechocystis sp. PCC 6803. Applied Microbiology and Biotechnology, 2016, 100(13):6091–6101.

5. Li, Y., Wang, X., Ge, X., Tian, P. High production of 3-hydroxypropionic acid in Klebsiella pneumoniae by systematic optimization of glycerol metabolism. Scientific Reports, 2016, 6:26932.

6. Xiong, X., Wang, X., Chen, S. Engineering of an L-arabinose metabolic pathway in Rhodococcus jostii RHA1 for biofuel production. Journal of Industrial Microbiology & Biotechnology, 2016, 43(7):1017–1025.

7. Xiong, X., Wang, X., Chen, S. Engineering of a xylose metabolic pathway in Rhodococcus strains. Applied and Environmental Microbiology, 2012, 78(16):5483–5491.

8. Wang, X., Sa, N., Tian, P., Tan, T. Classifying DNA assembly protocols for devising cellular architectures. Biotechnology Advances, 2011, 29(1):156–163.

专利成果

1. Lee, T. S., Wang, X. 2021. Fusion proteins useful for modifying terpenes. U.S. Appl. 17/207,097.