相佳佳，博士，特聘研究员，博士生导师，浙江大学杭州国际科创中心“求是科创学者（科创百人）计划”入选者。2012年获浙江大学高分子材料与工程专业学士学位，2018年获浙江大学生物化工专业博士学位，2009-2021年获浙江大学-斯坦福联合招收博士后项目资助从事博士后研究，2021年9月入职浙江大学杭州国际科创中心。

长期从事生物医用高分子材料、药物递送系统等方面的研究。以（共同）第一作者及通讯作者在Nature Biomedical Engineering，Advanced Materials，Nano Today，Advanced Science，Advanced Drug Delivery Reviews，ACS Applied Materials & Interfaces，Journal of Controlled Release等国际知名期刊发表论文10余篇，权国家发明专利6项，主持博后基金一项，担任Advanced Science等期刊审稿人。

论文发表：

Jiajia Xiang^#, Yihuai Shen^#, Yifan Zhang^#, Xin Liu, Quan Zhou, Zhuxian Zhou, Jianbin Tang, Shiqun Shao*, Youqing Shen*, Multipotent poly(tertiary amine-oxide) micelles for efficient cancer drug delivery. Advanced Science 2022, 2200173.

Jiajia Xiang^#, Xin Liu^#, Guiping Yuan, Runnan Zhang, Quan Zhou, Tao Xie, Youqing Shen*, Nanomedicine from amphiphilized prodrugs: Concept and clinical translation. Advanced Drug Delivery Reviews 2021, 179, 114027.

Kexin Liu^#, Jiajia Xiang^#, Guowei Wang, Hongxia Xu, Xiangrui, Liu, Jianbin Tang, Youqing Shen, Zhuxian Zhou*, Linear-dendritic polymer-platinum complexes forming well-defined nanocapsules for acid-responsive drug delivery.ACS Applied Materials & Interfaces 2021, 13, 44028-44040.

Jiajia Xiang^#, Peiwen Xing^#, Liu Xin, Peihong Shen, Shiqun Shao, Quan Zhou, Zhuxian Zhoua, Jianbin Tang, Youqing Shen*, Hydrogen sulfide-activatable prodrug-backboned block copolymer micelles for delivery of chemotherapeutics. Polymer Chemistry 2021, 12, 4167.

Quan Zhou^#, Jiajia Xiang^#, Lingqiao Hao, Xiaojie Xu, Zhuxian Zhou, Jianbin Tang, Yuan Ping, Youqing Shen*, Polyplex nanovesicles of single strand oligonucleotides for efficient cytosolic delivery of biomacromolecules. Nano Today 2021, 39, 101221.

Siqin Chen^#,Yin Zhong^#,Wufa Fan^#,Jiajia Xiang^#,Guowei Wang,Quan Zhou,Jinqiang Wang,Yu Geng,Rui Sun,Zhen Zhang,Ying Piao,Jianguo Wang,Jianyong Zhuo,Hailin Cong,Haiping Jiang,Jun Ling,Zichen Li,Dingding Yang,Xin Yao,Xiao Xu,Zhuxian Zhou,Jianbin Tang,and Youqing Shen*. Enhanced tumour penetration and prolonged circulation in blood of polyzwitterion–drug conjugates with cell-membrane affinity. Nature Biomedical Engineering 2021, 5, 1019-1037.

Shengjun Xu, Sunbin Ling, Qiaonan Shan, Qianwei Ye, Qifan Zhan, Guangjiang Jiang, Jianyong Zhuo, Binhua Pan, Xue Wen, Tingting Feng, Haohao Lu, Xuyong Wei, Haiyang Xie, Shusen Zheng, Jiajia Xiang*, Youqing Shen, and Xiao Xu*. Self-activated cascade-responsive sorafenib and USP22 shRNA co-delivery system for synergetic hepatocellular carcinoma therapy. Advanced Science 2021, 2003042.

Jiajia Xiang, Yinwen Li*, Yifan Zhang, Guowei Wang, Hongxia Xu, Zhuxian Zhou, Jianbin Tang, and Youqing Shen*. Polyphenol-cisplatin complexation forming core-shell nanoparticles with improved tumor accumulation and dual-responsive drug release for enhanced cancer chemotherapy. Journal of Controlled Release 2021, 330, 992-1003.

Chengyuan Dong^#, Quan Zhou^#, Jiajia Xiang*, Fusheng Liu*, Zhuxian Zhou*, Youqing Shen. Self-assembly of oxidation-responsive polyethylene glycol-paclitaxel prodrug for cancer chemotherapy. Journal of Controlled Release 2020, 321, 529-539.

Xinchi Jiang^#, Jiajia Xiang^#, Honghui Wu, Tianyuan Zhang, Danping Zhang, Qianhao Xu, Xiaoli Huang, Xianglei Kong, Jihong Sun, Yulan Hu, Kai Li, Yasuhiko Tabata, Youqing Shen*, and Jianqing Gao*.Neural stem cells transfected with reactive oxygen species–responsive polyplexes for effective treatment of ischemic stroke. Advanced Materials 2019, 31, 1807591.

Jiajia Xiang^#, Xin Liu^#, Zhuxian Zhou, Dingcheng Zhu, Quan Zhou, Ying Piao, Liming Jiang, Jianbin Tang, Xiangrui Liu, and Youqing Shen*. Reactive oxygen species (ROS)-responsive charge-switchable nanocarriers for gene therapy of metastatic cancer. ACS Applied Materials & Interfaces 2018, 10, 43352-43362.

Jiajia Xiang^#, Bihan Wu^#, Zhuxian Zhou, Shiqi Hu, Quan Zhou, Guowei Wang, Jianbin Tang, Xiangrui Liu, and Youqing Shen*. Synthesis and evaluation of a paclitaxel-binding polymeric micelle for efficient breast cancer therapy. Science China Life Science 2018, 61, 1-12.

Xin Liu^#, Jiajia Xiang^#, Dingcheng Zhu, Liming Jiang, Zhuxian Zhou, Jianbin Tang, Xiangrui Liu, Yongzhuo Huang, and Youqing Shen*. Fusogenic reactive oxygen species triggered charge-reversal vector for effective gene delivery. Advanced Materials 2016, 28, 1743-1752.

专利成果

申有青，周泉，相佳佳，徐昌活，郝玲巧，一种γ-谷氨酰转肽酶催化水解致电荷反转的聚合物及其在药物输送领域的应用，中国专利（ZL201710917814.5）。

申有青，吴碧寒，相佳佳，朴莹，一种聚乙二醇-聚赖氨酸/异硫氰酸酯键合物及其作为药物载体的应用，中国专利（ZL201810045332.X）。

徐骁，申有青，相佳佳，许圣均，凌孙彬，单巧南，一种用于癌症治疗的索拉非尼-基因共载纳米药物及其制备方法和应用，中国专利（ZL201911107774.3）。

周珠贤，刘珂鑫，相佳佳，唐建斌，刘祥瑞，申有青，聚乙二醇-树枝状聚赖氨酸/酸酐-顺铂复合物及其制备方法和应用，中国专利（ZL201911107774.3）。

徐骁，相佳佳，陶耀业，王建国，申有青，柯庆宏，岑贝妮，一种氧化响应去电荷的阳离子聚合物及其制备方法和应用，中国专利（ZL202011450807.7）。

徐骁，王建国，陶耀业，相佳佳，柯庆宏，申有青，一种缺氧响应的阳离子聚合物及其制备方法和应用，中国专利（ZL202011302610.9）。